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Quebecol Shows Potential to Alleviate Periodontal Tissue Damage and Promote Bone Formation in In Vitro Models

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Cardinal, Sébastien et Ben Lagha, Amel et Azelmat, Jabrane et Grenier, Daniel (2021). Quebecol Shows Potential to Alleviate Periodontal Tissue Damage and Promote Bone Formation in In Vitro Models. ACS Omega, 6 (42). p. 27791-27797.

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Résumé

Quebecol is a polyphenolic compound initially isolated from Canadian maple syrup in 2011. Recently, our group demonstrated in a macrophage model that quebecol inhibits the secretion of pro-inflammatory cytokines and reduces the activation of the NF-κB transcription factor. In this study, we further explored the therapeutic potential of quebecol against periodontal disease, an inflammatory disorder of bacterial origin affecting tooth-supporting tissues. More specifically, the effects of this natural compound on matrix metalloproteinase (MMP) activity and macrophage secretion, as well as on the mineralization activity of osteoblasts (bone-forming cells), were investigated. Results showed that exposing lipopolysaccharide (LPS)-treated macrophages to quebecol led to a significant decrease in the secretion of MMP-8 and MMP-9. In addition, quebecol dose dependently inhibited the catalytic activity of MMP-9. Quebecol also enhanced the mineralization activity of osteoblasts. This study brought forward additional evidence to support the potential of quebecol as a nutraceutical agent against periodontitis. -- Keywords : Immunology ; Anatomy ; Peptides and proteins ; Mineralization ; Inflammation.

Type de document : Article
Validation par les pairs : Oui
Information complémentaire : CC-BY-NC-ND 4.0 PMCID# PMC8552349
Mots-clés : Québécol Polyphénol Sirop d’érable Tissus Conservation Prévention Anti-inflammatoire Parodontite Croissance Cellule Os Modèle In vitro
Version du document déposé : Version officielle de l'éditeur
Départements et unités départementales : Département de biologie, chimie et géographie
Déposé par : DIUQAR UQAR
Date de dépôt : 04 nov. 2021 18:07
Dernière modification : 05 nov. 2021 13:39
URI : http://semaphore.uqar.ca/id/eprint/1910

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