Quebecol Shows Potential to Alleviate Periodontal Tissue Damage and Promote Bone Formation in In Vitro Models

Cardinal, Sébastien ORCID: https://orcid.org/0000-0003-4281-2691, Ben Lagha, Amel, Azelmat, Jabrane et Grenier, Daniel (2021). Quebecol Shows Potential to Alleviate Periodontal Tissue Damage and Promote Bone Formation in In Vitro Models. ACS Omega, 6 (42). pp. 27791-27797.

PDF Télécharger (1MB) | Prévisualisation

Résumé

Quebecol is a polyphenolic compound initially isolated from Canadian maple syrup in 2011. Recently, our group demonstrated in a macrophage model that quebecol inhibits the secretion of pro-inflammatory cytokines and reduces the activation of the NF-κB transcription factor. In this study, we further explored the therapeutic potential of quebecol against periodontal disease, an inflammatory disorder of bacterial origin affecting tooth-supporting tissues. More specifically, the effects of this natural compound on matrix metalloproteinase (MMP) activity and macrophage secretion, as well as on the mineralization activity of osteoblasts (bone-forming cells), were investigated. Results showed that exposing lipopolysaccharide (LPS)-treated macrophages to quebecol led to a significant decrease in the secretion of MMP-8 and MMP-9. In addition, quebecol dose dependently inhibited the catalytic activity of MMP-9. Quebecol also enhanced the mineralization activity of osteoblasts. This study brought forward additional evidence to support the potential of quebecol as a nutraceutical agent against periodontitis. -- Keywords : Immunology ; Anatomy ; Peptides and proteins ; Mineralization ; Inflammation.

Type de document :	Article
Validation par les pairs :	Oui
Information complémentaire :	CC-BY-NC-ND 4.0 PMCID# PMC8552349
Mots-clés :	Québécol Polyphénol Sirop d’érable Tissus Conservation Prévention Anti-inflammatoire Parodontite Croissance Cellule Os Modèle In vitro
Départements et unités départementales :	Département de biologie, chimie et géographie
Date de dépôt :	04 nov. 2021 18:07
Dernière modification :	02 oct. 2023 17:28
URI :	https://semaphore.uqar.ca/id/eprint/1910