“Bleu VS Yellow”: Marennine and extracellular polysaccharides for potential application in cosmetic and pharmaceutical applications

Chehouri, Mariame, Pédron, Élodie, Genard, Bertrand, Doiron, Kim, Fortin, Samuel ORCID: https://orcid.org/0000-0003-1738-2351, Bélanger, William, Deschênes, Jean-Sébastien et Tremblay, Réjean ORCID: https://orcid.org/0000-0003-2590-8915 (2025). “Bleu VS Yellow”: Marennine and extracellular polysaccharides for potential application in cosmetic and pharmaceutical applications. The Microbe, 8 (100448).

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Résumé

Haslea ostrearia, a widely distributed marine pennate diatom, produces the unique blue pigment marennine and various extracellular polysaccharides (EPS), exhibiting promising bioactive properties. Previous studies have demonstrated the antibacterial, antioxidant, and antiproliferative effects of purified marennine extracts, while EPS fractions remain primarily understudied despite their potential applications in dermatology and cosmetics. Based on these prior findings, we hypothesized that marennine and EPS could influence skin-related biological processes, particularly gene expression related to hydration and aging, as well as lipid metabolism. To test this hypothesis, we investigated the effects of marennine and EPS at different concentrations (1, 10 and 100 µg mL⁻¹) on dermal fibroblast skin cells. Gene expression analysis targeted key markers associated with hydration and anti-aging, while lipidomic profiling assessed potential alterations in skin cell lipid composition. Our results demonstrated a significant upregulation of genes linked to skin hydration and elasticity, supporting the bioactive potential of these compounds. However, lipidomic analyses revealed no significant changes in the structural lipid composition of the skin cells across all tested concentrations. These findings highlight the potential of marennine and EPS as bioactive ingredients for cosmetic formulations aimed at improving skin hydration and anti-aging properties. Furthermore, their bioactivity suggests possible pharmaceutical applications, particularly in dermatological treatments requiring natural bioactive compounds with antioxidative and protective properties.

Type de document :	Article
Validation par les pairs :	Oui
Mots-clés :	Haslea ostrearia ; Marennine ; Exopolysaccharides (EPS) ; Cosmétiques ; Lipidomique ; Cellules cutanées / Haslea ostrearia ; Marennine ; Exopolysaccharides (EPS) ; Cosmetics ; Lipidomic ; Dermal skin cells.
Départements et unités départementales :	Institut des sciences de la mer de Rimouski (ISMER)
Date de dépôt :	31 mars 2026 14:14
Dernière modification :	31 mars 2026 14:14
URI :	https://semaphore.uqar.ca/id/eprint/3524